Last updated: August 11, 2021

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DMSO is supposed to help against inflammations, swellings and sprains. Nevertheless, you are not yet convinced of its effect and would like to learn more about the correct application, scientific background and necessary purchase criteria of DMSO? Then you've come to the right place!

In our big DMSO test 2021 we will provide you with all the necessary background information and explain it to you in detail. You will not only get tips from us, but also learn about the healing effect of DMSO. We will also tell you about the possible side effects and other important information along the way.




The most important facts

  • DMSO has a multifaceted effect and is also called a miracle cure due to its anti-inflammatory and pain-relieving effect.
  • DMSO is available in different dosage forms. You can buy DMSO as an ointment, cream, spray or as a pure liquid (99.9%). With pure DMSO, you should always dilute the concentration with water before use.
  • Side effects depend especially on the dosage and can occur during application. Therefore, you should always inform yourself well beforehand and, at best, get advice from a doctor.

The Best DMSO: Our Picks

Buying and evaluation criteria for DMSO

When buying DMSO, you can look at various aspects, such as:

By making the right choice for you, you can save money and also ensure that you do not give your body anything it does not need. Therefore, always make sure that the product is of high quality and, if necessary, ask to see the manufacturer's certificates.

Dosage form

Since DMSO is available in many forms, everyone can decide for themselves which form is ideal for taking.

In the following table, we have briefly summarised the dosage forms of DMSO products:

Dosage form Examples
Semi-solid Ointment, cream, gel
Liquid Drops, spray

Now that you have been introduced to some of our DMSO products, it may be easier for you to decide on the right product. With regard to this, we distinguish between different dosage forms of DMSO.

Dilution

When buying a DMSO product, you should pay special attention to the correct application. Therefore, we recommend that you always read the product description carefully and inform yourself about the correct application. Basically, DMSO is for internal and external use.

If you want to take DMSO in the form of drops, you should note the following: When applying to the skin, itching can occur if the concentration is too high.

Therefore, you have to find the right mixture for yourself between water and the respective DMSO concentration. It is difficult to determine an exact value here. The same applies to oral intake.

If your mixture is too strong, wash the affected area of your skin with a little water and continue to dilute the mixture until you do not feel any irritation after application.

Fields of application

In principle, you can use DMSO both internally and externally. In the following, we will tell you which areas of application DMSO is used for:

  • For sports injuries / pain
  • For swellings
  • For circulatory disorders
  • For inflammations
  • For sprains

Basically, we recommend that you always consult a doctor so that he can give you information about the correct application. He will also tell you about the risks and side effects.

Storage conditions

When using DMSO products, you should always make sure that they are stored correctly and safely. We recommend that you label your DMSO products so that there is no risk of confusion with other products. Furthermore, you should store DMSO in a dry place and avoid direct sunlight.

Since the substance is flammable, it makes logical sense to avoid heat and warmth. DMSO is also hygroscopic and should therefore not come into contact with moisture during storage.

Disposal

DMSO products should be disposed of as follows: If the waste cannot be recycled, you must dispose of your waste according to local regulations.

Check with the manufacturer first or contact them if you are unsure of how to dispose of the product. The manufacturer can give you better information and help you with your concerns.

Guide: Frequently asked questions about DMSO answered in detail

In order to inform you comprehensively about the effectiveness of lady's mantle and to give you an understanding of the current state of science, we have summarised all the important information in the following sections.

What is DMSO and how does it work?

DMSO or dimethyl sulphoxide is supposed to help against pain, swelling and inflammation. This is precisely because DMSO has pain-relieving, antioxidant, anti-inflammatory and vasodilator properties. As already mentioned, you can buy DMSO pure (99.9%) or in combination with other active ingredients.

DMSO is also a colourless liquid that is a by-product of pulp in the production of paper. Since DMSO has many applications, the sulphur compound is also seen as a useful medicine due to its properties (1).

Effect on skin diseases

Skin diseases such as acne or neurodermatitis are annoying skin diseases that are not easy to treat. In the USA, acne is by far the most common skin disease, which can develop due to increased sebum production and cause inflammatory reactions (2).

It is precisely the intense itching or inflammation on the skin caused by acne or atopic dermatitis that causes sufferers to experience pain. With medication, it can usually be observed that the healing of the affected areas progresses very slowly (3).

However, it could be proven in this study that a DMSO ointment can reduce the burning and itching on the skin after application (3).

Effect on eye diseases

Eye diseases are often treated with DMSO drops. This is because the DMSO drops can, among other things, strengthen the tissue in the eye.

DMSO drops have a positive effect on eye diseases (Photo source: Amanda Dalbjörn / unsplash)

However, you should be aware that high concentrations of DMSO can irritate the eye and cause a counter-effect. Low concentrations of DMSO, on the other hand, have an anti-inflammatory effect (4).

Effect on arthrosis

Those affected by arthrosis suffer from an inflammatory disease of the joints. Most people turn to DMSO to relieve their pain and improve their mobility.

Studies have shown that joint pain can be relieved by the use of DMSO. In combination with other medicines, DMSO is able to increase the effect and relieve severe pain in the joints for a certain period of time (5).

Nevertheless, no exact result can be established for treatment with DMSO. Some studies have poor methodology and are therefore only trustworthy to a certain extent. Therefore, more studies are needed to evaluate the effectiveness of DMSO in the long term (6).

When and for whom is it useful to take DMSO?

There is no specific target group that should use DMSO. This is because DMSO has a particularly multifaceted effect and can be applied to various areas.

DMSO is basically suitable for everyone who suffers from complaints such as muscle tension, pain, arthrosis, acne, eye diseases or skin diseases. As you can see from this, the use of DMSO does not only affect a certain group of people.

Basically, we recommend that you talk to a doctor about taking it beforehand and get thorough advice. Allergy sufferers in particular should inform themselves about DMSO and not take or apply too much of the product at first.

What are the possible side effects of DMSO?

You have now received information about the effects of DMSO from us in the above section. As you might have guessed, there are also side effects that you need to be aware of. We will now tell you what these might be.

Skin reactions are the most common side effects of DMSO in humans. Basically, the dose plays a decisive role in the occurrence of side effects (7).

As a conclusion, it can be said that side effects do occur, but in most cases they are very mild and can only occur over a short period of time (7).

In addition, side effects such as reddening of the skin, itching, headaches, dryness of the skin, dizziness, abdominal cramps, rashes or even shortness of breath can occur.

How much do DMSO products cost?

During our research, we found out that the price range of DMSO products can vary greatly among each other. To help you compare the products, we have put together a price overview in a table:

Dosage form price
Drops from about 10 euros / 100 millilitres
Ointment / cream from about 20 euros
Spray from about 15 euros

Depending on how high the concentration of DMSO is in the product and which dosage form you ultimately choose, the price will differ again. You should be aware that the information in the table is not exact and is only an overview. This means that you can also get drops much more expensive or cheaper.

What types of DMSO are there?

As you have already learned from us, there are different types of DMSO products. In general, the following three types are distinguished:

type Description
DMSO drops The most popular and most commonly purchased variety is DMSO drops. DMSO drops usually come in medical glass bottles with a dosage aid. In general, most manufacturers or customers recommend buying pure and distilled DMSO instead of ointments.
DMSO ointment / cream For external use, most people turn to ointments or creams. This is a finished product that can be applied directly to the skin.
DMSO spray DMSO sprays can also be bought in shops for an average price. Depending on the manufacturer, you can buy the sprays with DMSO in the form of a glass bottle or a plastic container.

The advantages and disadvantages of the three types are explained in more detail below.

DMSO drops

Pure DMSO is offered in liquid form. According to our research, DMSO in the form of drops is the most popular variant among customers.

Advantages
  • practical dosing aid (e.g. pipette)
  • DMSO drops are mainly found in light-protected and medical glass bottles
  • wide range of applications
Disadvantages
  • Glass bottles can break
  • taste when taken orally can be very strong
  • over- and under-dosing can occur if administered incorrectly

For better dosing, most products are equipped with a dosing aid.

This can be an integrated pipette, for example. With this in mind, you should always buy DMSO drops in a medical glass bottle that is protected from light and in dark colours. Basically, we advise you to always use glass bottles.

DMSO ointment / cream

DMSO ointments and creams are also very popular. Ointments with DMSO are used especially for sports injuries. Since the ointments already exist in diluted form, you do not have to dilute them with water beforehand, but can apply them directly to the skin.

Depending on the manufacturer, the ointment contains either a higher or lower percentage of DMSO.

Advantages
  • easy to use
  • quick to apply
  • inexpensive in most cases
Disadvantages
  • Usually for external use only
  • Most products come in plastic containers
  • Not necessarily suitable for people with skin disease

Basically, you should always think carefully about the DMSO product before you buy it. The more background information you acquire, the more likely you are to find the right product for you. If you put a lot of time into your search, you will avoid bad purchases and dissatisfaction.

DMSO Spray

DMSO sprays are also popular for external use. Besides ointments and creams, most sprays also come in plastic containers. In fact, there are also some manufacturers who offer the sprays in glass bottles.

Advantages
  • easy to use
  • average price
  • easy to transport
Disadvantages
  • exact dosage is not possible or difficult
  • contents can be inhaled

Just like ointments, most sprays contain only a certain amount of DMSO. Accompanying substances such as preservatives are also contained in this type of DMSO. It is therefore a finished product that can be used directly.

How should DMSO be dosed?

When dosing with DMSO liquid, the following should be observed: Before taking or using the concentration, it should always be diluted with water or taken together with water.

You should be aware that the exact dosage cannot be determined. This is because DMSO is used in many areas and everyone has a different clinical picture.

The dosage depends on the severity of the symptoms of the person concerned. In addition, factors such as internal or external application play an important role.

In general, you should never apply too much ointment or cream to your skin when using it externally, as this form of application can quickly take effect on your skin and its effects unfold rapidly.

If you want to take or apply pure DMSO in the form of drops, you should observe the following:

On the internet, the recommended guideline for daily internal use is 0.1 kilogram per body weight. The mixing ratio is very important here - you should dilute the DMSO liquid with a little water beforehand or drink it together with water.

What alternatives are there to DMSO?

Besides DMSO, there are other medicines that have similar properties and are said to have healing and health-promoting effects. We have briefly explained two alternatives to DMSO in a table.

Alternative Description
MSM (methylsulfonylmethane) An alternative to DMSO is MSM. This is a dietary supplement known as organic sulphur and is said to have an anti-inflammatory effect. In addition, recent research suggests that MSM may one day be able to help treat various types of cancer (8).
CDL (chlorine dioxide solution) CDL is able to detoxify our bodies through oxidation. In the following study, it was proven in an experiment with CDL-containing mouthwash using test persons that dental plaque, bad breath, the number of bacteria and tongue coating in the mouth were reduced over the tested period of time. (9) . In addition, the effectiveness of CDL against pathogens was also proven in the following study: Drinking water infested with cryptosporidium parasites was treated by researchers with a certain amount of CDL, which then eliminated 97% of the parasites after a short time (10).

What helps against the stinking smell of DMSO?

You may have found out that DMSO has an unpleasant smell when searching on the internet or in shops. Many also compare the stinky smell to garlic or onions. Therefore, some complain about the smell and try to neutralise it with different variants.

DMSO

Studies have proven that DMSO can help with skin diseases and relieve pain. Skin diseases include acne, for example. (Image source: Joseph Mocira / pixabay)

Basically, however, it is very difficult to neutralise the smell. Therefore, we recommend that you take the medicine at home or apply it and let it take effect there. Unfortunately, there is still no known helpful method to completely eliminate the unpleasant odour in a natural way.

With repeated application, most people will not notice the smell, but other people will smell it as soon as you go outside.

The intensity of the smell depends on the area of application and the dosage. However, there is no denying that you may notice a stinky smell even with a small amount.

Image source: Kjerstin Michaela Noomi Sakura Gihle Martinsen Haraldsen / Pixabay

References (10)

1. J Clin Aesthet Dermatol. 2012 Sep; 5(9): 24–26. PMCID: PMC3460663 PMID: 23050031 Kara Capriotti, MDcorresponding authora and Joseph A. Capriotti, MDb aBryn Mawr Skin and Cancer Institute, Rosemont, Pennsylvania bOcean Ophthalmology Group, North Miami Beach, Florida corresponding authorCorresponding author.
Source

2. Stephen Titus 1 , Joshua Hodge Affiliations expand PMID: 23062156
Source

3. L Murdoch PMID: 10298633
Source

4. Effects of dimethyl sulfoxide on ocular inflammation C Hanna, F T Fraunfelder, S M Meyer PMID: 319730
Source

5. [Article in Dutch] R A Douwes 1 , J H van der Kolk Affiliations expand PMID: 9537081
Source

6. S Brien 1 , P Prescott, N Bashir, H Lewith, G Lewith Affiliations expand PMID: 18417375 DOI: 10.1016/j.joca.2008.03.002
Source

7. ennedikte Kollerup Madsen 1 , Maria Hilscher 1 , Dennis Zetner 1 , Jacob Rosenberg 1 Affiliations expand PMID: 31489176 PMCID: PMC6707402 DOI: 10.12688/f1000research.16642.2
Source

8. Matthew Butawan, Rodney L. Benjamin, and Richard J. Bloomer Nutrients. 2017 Mar; 9(3): 290. Published online 2017 Mar 16. doi: 10.3390/nu9030290 PMCID: PMC5372953 PMID: 28300758
Source

9. Trials. 2010; 11: 14. Published online 2010 Feb 12. doi: 10.1186/1745-6215-11-14 PMCID: PMC2831889 PMID: 20152022 Kayoko Shinada,corresponding author1 Masayuki Ueno,1 Chisato Konishi,1 Sachiko Takehara,1 Sayaka Yokoyama,1 Takashi Zaitsu,1 Mari Ohnuki,1 Fredrick Allan Clive Wright,2 and Yoko Kawaguchi1
Source

10. J E Peeters, E A Mazás, W J Masschelein, I Villacorta Martiez de Maturana, and E Debacker Appl Environ Microbiol. 1989 Jun; 55(6): 1519–1522. PMCID: PMC202897 PMID: 2764564
Source

Why you can trust me?

Dimethyl Sulfoxide
J Clin Aesthet Dermatol. 2012 Sep; 5(9): 24–26. PMCID: PMC3460663 PMID: 23050031 Kara Capriotti, MDcorresponding authora and Joseph A. Capriotti, MDb aBryn Mawr Skin and Cancer Institute, Rosemont, Pennsylvania bOcean Ophthalmology Group, North Miami Beach, Florida corresponding authorCorresponding author.
Go to source
Diagnosis and treatment of acne
Stephen Titus 1 , Joshua Hodge Affiliations expand PMID: 23062156
Go to source
Dimethyl sulfoxide (DMSO)--an overview
L Murdoch PMID: 10298633
Go to source
Clinical Trial Ann Ophthalmol . 1977 Jan;9(1):61-5.
Effects of dimethyl sulfoxide on ocular inflammation C Hanna, F T Fraunfelder, S M Meyer PMID: 319730
Go to source
[Dimethylsulfoxide (DMSO) in horses: a literature review]
[Article in Dutch] R A Douwes 1 , J H van der Kolk Affiliations expand PMID: 9537081
Go to source
Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis
S Brien 1 , P Prescott, N Bashir, H Lewith, G Lewith Affiliations expand PMID: 18417375 DOI: 10.1016/j.joca.2008.03.002
Go to source
Adverse reactions of dimethyl sulfoxide in humans: a systematic review
ennedikte Kollerup Madsen 1 , Maria Hilscher 1 , Dennis Zetner 1 , Jacob Rosenberg 1 Affiliations expand PMID: 31489176 PMCID: PMC6707402 DOI: 10.12688/f1000research.16642.2
Go to source
Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
Matthew Butawan, Rodney L. Benjamin, and Richard J. Bloomer Nutrients. 2017 Mar; 9(3): 290. Published online 2017 Mar 16. doi: 10.3390/nu9030290 PMCID: PMC5372953 PMID: 28300758
Go to source
Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial
Trials. 2010; 11: 14. Published online 2010 Feb 12. doi: 10.1186/1745-6215-11-14 PMCID: PMC2831889 PMID: 20152022 Kayoko Shinada,corresponding author1 Masayuki Ueno,1 Chisato Konishi,1 Sachiko Takehara,1 Sayaka Yokoyama,1 Takashi Zaitsu,1 Mari Ohnuki,1 Fredrick Allan Clive Wright,2 and Yoko Kawaguchi1
Go to source
Effect of disinfection of drinking water with ozone or chlorine dioxide on survival of Cryptosporidium parvum oocysts.
J E Peeters, E A Mazás, W J Masschelein, I Villacorta Martiez de Maturana, and E Debacker Appl Environ Microbiol. 1989 Jun; 55(6): 1519–1522. PMCID: PMC202897 PMID: 2764564
Go to source
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