Last updated: August 12, 2021

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Welcome to our big glutathione test 2021. Here we present all the glutathione preparations that we have tested in detail. We have compiled detailed background information and added a summary of customer reviews on the internet.

We would like to make your purchase decision easier and help you find the best glutathione preparation for you.

You will also find answers to frequently asked questions in our guide. If available, we also offer interesting test videos. Furthermore, you will also find some important information on this page that you should definitely pay attention to if you want to buy glutathione.




The most important facts

  • Glutathione is a substance that is found in every cell of the body. The production of this important substance unfortunately decreases in the course of life, so that a supply of glutathione makes sense in certain situations.
  • Glutathione is a component of vital amino acids and helps the human body fight free radicals.
  • Glutathione can also be taken by vegans without hesitation, as synthetic glutathione is a pure food supplement without animal origin.

The Best Glutathione: Our Picks

Guide: Questions you should ask yourself before buying glutathione

What exactly is glutathione?

Glutathione consists of the three amino acids glutamate, cysteine and glycine and is therefore also called tripeptide. Basically, glutathione is an important component of every cell in our body.

Glutathione is traded on the German market as a food supplement and is therefore freely available. (Image source: 123rf.com / 65074561)

This substance protects our organism from harmful dangers and is therefore considered vital.

According to the latest findings, glutathione is able to enter the cells directly. The evidence for this was provided, among other things, by a study from America. This showed that the body's own glutathione level could be increased by up to 35%. This was particularly visible in the blood cells, plasma and lymphocytes. (1)

If the production of glutathione decreases and there is accordingly too little of the active substance in our cells, our body has a problem fending off the dangers.

The neuronal system also depends on glutathione to maintain its functions. According to studies, a significant reduction in the amount of the substance is said to promote cell death.

As a result, some of the body's functions become unstable and the person may feel ill. At first glance, the cause of the disease is often not obvious.

This connection could also be interesting with regard to neurodegenerative diseases, which include Alzheimer's and Parkinson's disease. Scientific studies have provided evidence that glutathione is indeed able to delay the onset of the disease processes or mitigate further progression. (2)

It is striking that people with liver diseases often have reduced glutathione levels. It does not matter whether the disease can be attributed to heavy alcohol consumption or hepatitis.

Basically, the liver provides the largest amount of glutathione, which is why the connection between organ health and the available glutathione level is also interesting.

In a model on animals, however, it was found that mice with liver cirrhosis lived longer when the amount of glutathione was increased. (3)

It is also clear that the human respiratory organ is very sensitive to oxidative stress. At the same time, it has the highest demand for glutathione. According to studies, the substance can be counted among the most effective antioxidants that protect the lungs from external influences. (4)

Another study showed a statistically significant positive effect on sperm motility, especially on the percentage of forward movement. (5)

How is glutathione normally located in our body?

Every cell in our body is capable of producing glutathione itself. Since our liver is generally the central organ of our body for detoxification, the liver cells make the most glutathione. The highest concentration of glutathione is therefore found in this organ.

But glutathione can also be added to the human body through food. Especially with meat, fruit and vegetables, the glutathione store can be filled up.

However, it is important that the food is freshly prepared and then eaten immediately. Preserved foods contain much less glutathione.

How much glutathione should a person take in daily?

Scientific studies have proven that about 250 mg of glutathione should be taken in daily by the body through food. With this we can cope with the fight against harmful environmental factors and feel healthy.

In this day and age, however, it is unfortunately the case that our eating habits have changed greatly in contrast to the past.

Ready-made meals or meals from a can are cooked for so long in advance that unfortunately few healthy components remain.

Glutathione is also only contained in a very low concentration in these types of dishes.

If you have been eating this way, you may only be taking in 50-60 mg of glutathione daily through food. This is definitely too little to keep the glutathione level constant between 200 and 300 mg.

Which diseases favour a low glutathione level?

First and foremost, the widespread disease "obesity" is listed here. This is not only due to the consumption of convenience food, but of course it plays a major role.

If you have too much excess fat in your body, you break down antioxidants as a result. This in turn leads to very low glutathione levels.

For some other diseases, scientific studies have proven the connection with a low level of glutathione.

These include all cancers, kidney diseases, lung diseases, Parkinson's disease and some eye diseases such as cataracts and macular degeneration.

So if you have any of the above diseases, you can expect to have low glutathione levels. In this case, it can't hurt to take glutathione supplements.

What environmental factors promote low glutathione?

Environmental pollutants and chemicals can also lower the amount of glutathione in the body.

These include first and foremost UV radiation and other ionising radiation.

We cannot always avoid exposure to these pollutants, but we can be aware of them and act accordingly.

So if you are experiencing vague symptoms of illness, it is important to remember that the cause could be that you have too little glutathione stored in your cells.

What can inhibit the production of glutathione?

Of course, you are aware that smoking is generally recognised as being very harmful.

If you are a smoker, you should be aware that this can also lead to a lack of glutathione in your body.

This is especially true if you are a heavy smoker - from about 20 cigarettes per day.

Excessive alcohol consumption can also be equated with smoking. There is nothing wrong with a glass of wine after a good - home-made - meal.

But regular drinking of alcohol not only leads to dependence or addiction, but is also a factor in having too little glutathione in your body.

Taking other medications also leads to low glutathione levels. These include not only medicines prescribed by your doctor, but also over-the-counter medicines.

Taking painkillers or medication for colds is already part of everyday life for many people. All of these are additional toxins that the body has to break down.

So if you feed your body a lot of toxins every day, you shouldn't be surprised if it stops functioning properly at some point. (Picture source: 123rf.com / 62635780)

Does the production of glutathione decrease with age?

In contrast to the past, people today are getting older overall. On the one hand, of course, this is due to the ever-improving medical possibilities, but on the other hand, it is also due to research into ageing.

There are now many scientific papers on how ageing works and why it happens at all.

In this context, the following study is interesting: several researchers have closely examined 100-year-olds, of which there are several in the world.

It was found that these people had very high levels of glutathione. From this point on, it was clear that glutathione definitely plays a major role in ageing.

The more glutathione that is present in the body, the greater the chances that a person will grow old.

Incidentally, the 100-year-olds tested were not given glutathione externally in the form of tablets.

For these people, the only decisive factors were a healthy lifestyle and a food intake that was always freshly prepared.

Which foods contain particularly high amounts of glutathione?

Of course, there are foods that contain a lot of glutathione and there are foods in which the amount is low or even non-existent. But there is another distinguishing feature that should not be underestimated.

It depends on how and when the product was processed. It makes a big difference whether the goods are consumed immediately after harvest or slaughter or whether they have been preserved.

In most cases, the glutathione content is naturally higher in fresh produce. A liver, for example, contains 737 mg of glutathione directly after slaughter.

This makes it the best of all foods. However, this value only applies in a really freshly slaughtered state.

If the liver is sold afterwards - i.e. if it is preserved - the glutathione content is only 120-275 mg.

So you can see that only very fresh food is suitable for increasing the glutathione level in your body.

Basically, you should remember that foods that are prepared for a long shelf life can contain almost no glutathione at all. This is especially the case with canned foods.

The contents are heated to such a high temperature that in most cases there is no glutathione left. Incidentally, this applies to all healthy substances.

But even dried foods or those that have been cured or smoked contain hardly any appreciable traces of glutathione.

The only exception is in products that have been shock-frozen immediately after slaughtering or harvesting.

Food from the frozen section therefore contains the same number of vitamins, trace elements and also glutathione as in a fresh state.

Overview of some foods with glutathione content (per 100 g)

Food Fresh or raw In store or cooked
Liver 373 mg 120 - 275 mg
Muscle meat of beef 75 mg 20 mg
Oranges 7.3 mg 4.2 mg
Potatoes 7.1 mg 13.6 mg
Carrots 2.2 mg 5.8 mg

Decision: Which types of glutathione are there and which is the right one for you?

Basically, you can distinguish between 4 different types of glutathione:

  • Glutathione in capsules
  • Glutathione as a liquid substance
  • Glutathione in ointments
  • Glutathione for intravenous administration

What distinguishes glutathione in capsules and what are the advantages and disadvantages?

Most dietary supplements that are intended to supply the body with glutathione are offered as capsules.

In addition to the active ingredient glutathione, other important foods can be added.

The capsule can also be used to control where the contents can unfold.

Ideally, the glutathione is only released in the intestinal area, because in the stomach it would be broken down into the three original components by the digestive juices.

Advantages
  • Due to the enteric capsule, the active ingredient glutathione is only released in the intestine
  • Important additives can be added to the capsule
  • Capsules can be swallowed easily
  • The daily requirement of glutathione is covered with a single capsule.
Disadvantages
  • People who for some reason cannot swallow "thick" tablets are out of luck
  • Unfortunately, this form is unsuitable for people with stomach problems
  • The dosage cannot be changed because the capsules are difficult to divide.

What distinguishes glutathione as a liquid substance and what are the advantages and disadvantages?

If, for whatever reason, you can't swallow tablets, you can get help here. Glutathione is also available in liquid form.

These are usually spray cans with which the liquid glutathione can be administered orally. The handling is very simple.

Some experts are also convinced that the oral intake of glutathione has a much faster effect on the organism. The active ingredient is directly absorbed through the mucous membranes and quickly supplied to the body.

Advantages
  • Drops with glutathione can be taken directly or mixed with other liquids
  • Glutathione as a spay can be taken quickly and discreetly in almost all situations
  • The dosage of glutathione can be changed yourself.
Disadvantages
  • The optimal dosage does not succeed at first go in order to achieve the desired effect
  • Since not all of the active substance is absorbed exclusively through the mucous membranes, a small part of the glutathione nevertheless reaches the stomach unprotected and is decomposed there without acquiring the actual effect.

What are the advantages and disadvantages of glutathione in ointments?

The active ingredient glutathione not only helps inside the body, but also if you have problems with your skin. Special ointments and tinctures have been developed for this purpose, which are simply applied to the skin.

A nice side effect of using glutathione on the skin is that age spots or dark spots on the skin are lightened.

Some consumers of glutathione often use the ointments just to lighten the skin.

Advantages
  • The active ingredient glutathione is not administered orally, but can simply be applied to the skin
  • Ideal for skin problems of all kinds - especially for lightening dark age spots
  • The ointments contain additional nutrients for healthy and wrinkle-free skin.
Disadvantages
  • Does not work inside the body against free radicals
  • Only useful for skin problems

What are the advantages and disadvantages of glutathione for intravenous administration?

If you have a serious nerve disease, you should seek medical treatment. The same applies if you have a cancer that needs to be treated with certain chemotherapeutic drugs.

In most cases, your doctor will decide that the active ingredient glutathione can contribute significantly to your healing.

Often, glutathione has to be given in a very high concentration. In this case, your doctor will probably want to inject you with the active substance glutathione.

In this case, there are ampoules whose contents can be injected intramuscularly or intravenously. However, only your doctor can decide this, because the ampoules are prescription drugs.

Advantages
  • Can be administered in a high dose intravenously or intramuscularly
  • The injection can be done by yourself
  • Can be administered in a very high dose
  • The effect is very fast.
Disadvantages
  • Ampoules can only be ordered from pharmacies with a doctor's prescription
  • There may be some reddening of the skin at the injection sites.

Buying criteria: You can use these factors to compare and evaluate glutathione

In the following, we would like to show you which factors you can use to compare and evaluate glutathione. This will make it easier for you to decide whether a certain form of glutathione is suitable for you or not.

In summary, these are:

  • Dosage form
  • Dosage of the ingredient
  • Additional ingredients

Glutathione is available in many variations on the open market. At first glance, there are few distinguishing features, as the active ingredient glutathione is in the foreground in all products.

Nevertheless, there are some distinguishing features that are geared to the personal interests of consumers.

Dosage forms of glutathione

In most cases, a lack of glutathione is compensated by dietary supplements. The most common form is the supply of capsules.

The capsule walls consist of enteric substances so that the glutathione is only released in the intestine. From there, it is distributed in the body in such a way that it has a detoxifying effect.

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Glutathione in liquid form is also a common way to absorb the active ingredient in the body. So if you already have to take a lot of tablets elsewhere, you might be glad of the option of taking drops or sprays.

The taste of the drops may take some getting used to, but the liquid can be added to other food or drink in most cases.

So you can choose the taste and also the concentration of the substance yourself.

If you only want to combat skin problems with glutathione, you should buy an ointment containing glutathione.

If you also want to conceal age spots, a paste for spreading is ideal. You should be aware that an ointment does not work inside your body.

Glutathione administered intravenously belongs in expert hands. You can inject yourself with the active ingredient, but you need a prescription from your doctor to buy the ampoules.

Dosage of the ingredient glutathione

The capsules contain a certain concentration - usually around 250-300 mg of glutathione. This corresponds to the daily requirement of a person who has a low glutathione level.

This usually replenishes the depot and the person already feels much better.

If, on the other hand, your glutathione level tends towards zero, you should pay attention to a higher dosage of glutathione. There are also some preparations on the market that offer the active ingredient from 400 mg upwards.

If you are undergoing medical treatment for your symptoms anyway, you can ask your doctor about it. He or she could prescribe a higher concentration for you as an injection. You can then order these ampoules from the pharmacy.

For the liquid form of glutathione, you should read the package leaflet carefully. It should tell you exactly how many drops you need per day.

Otherwise, you can only try to slowly introduce glutathione. Since the absorption of glutathione in your body has no side effects, it should not be a problem to gradually reduce the amount.

Additional ingredients

You will not find a product on the open market that contains only glutathione. Each manufacturing company will create their tablets, ointments or tinctures according to their own recipes.

The active ingredient glutathione will be present as the main ingredient, but other additional substances may be added to a capsule or ointment.

Sometimes these very additional ingredients are brought to the fore as purely promotional measures.

In most cases, these additives consist of further vitamins or other food supplements. In most cases, the intake is harmless.

Facts worth knowing about glutathione

Why are commercial products called "reduced" glutathione?

Artificially produced glutathione is a compound of amino acids whose molecules have been reduced.

This is the only way that glutathione can be effective in your body.

Does glutathione also help the environment?

Plants use glutathione to absorb harmful substances from the environment. Aquatic plants, for example, bind toxic substances from the water in their own cells and then repel them.

Other plants, for example, draw heavy metals or pesticides from the air and store them.

The air is thus freed from pollutants and the toxins are simply disposed of when the plants are harvested.

Image source: unsplash.com / Anastasiia Ostapovych

References (5)

1. John P Richie, Sailnendra Nichenametla, Ana Calcagnotto, Wanda Neidig, Todd Schell, and Joshua E Muscat. Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation. The Faseb Journal. April 2013; Vol. 27, No. 1_supplement.
Source

2. Chava B. Pocernicha, D. Allan Butterfield. Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease. Biochim Biophys Acta. 2012 May; 1822(5): 625–630.
Source

3. Ying Chen, Elisabet Johansson, Yi Yang, Marian L. Miller. Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc knockout mice providing a model for hepatic cirrhosis. J Hepatol. 2010 Dec; 53(6): 1085–1094..
Source

4. I Rahman, W MacNee. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. Sep 2000; 16 (3), 534-54.
Source

5. A Lenzi, F Culasso, L Gandini, F Lombardo, F Dondero. Placebo-controlled, Double-Blind, Cross-Over Trial of Glutathione Therapy in Male Infertility. Hum Reprod. Oct 1993; 8 (10), 1657-62.
Source

Why you can trust me?

Wissenschaftliche Studie
John P Richie, Sailnendra Nichenametla, Ana Calcagnotto, Wanda Neidig, Todd Schell, and Joshua E Muscat. Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation. The Faseb Journal. April 2013; Vol. 27, No. 1_supplement.
Go to source
Wissenschaftliche Studie
Chava B. Pocernicha, D. Allan Butterfield. Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease. Biochim Biophys Acta. 2012 May; 1822(5): 625–630.
Go to source
Wissenschaftliche Studie
Ying Chen, Elisabet Johansson, Yi Yang, Marian L. Miller. Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc knockout mice providing a model for hepatic cirrhosis. J Hepatol. 2010 Dec; 53(6): 1085–1094..
Go to source
Wissenschaftliche Studie
I Rahman, W MacNee. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. Sep 2000; 16 (3), 534-54.
Go to source
Wissenschaftliche Studie
A Lenzi, F Culasso, L Gandini, F Lombardo, F Dondero. Placebo-controlled, Double-Blind, Cross-Over Trial of Glutathione Therapy in Male Infertility. Hum Reprod. Oct 1993; 8 (10), 1657-62.
Go to source
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