Last updated: August 11, 2021

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Welcome to our big nattokinase test 2019. Here we present all the nattokinase preparations that we have tested in detail. We have compiled detailed background information for you and also added a summary of customer reviews on the internet. We would like to make your purchase decision easier and help you find the best nattokinase preparation for you.

You will also find answers to frequently asked questions in our guide. Furthermore, you will also find some important information on this page that you should definitely pay attention to if you want to buy nattokinase.

The most important facts

  • Nattokinase is a protein that is extracted as an enzyme from the Japanese soybean dish natto .
  • The enzyme is said to have fibrinolytic properties. This means that it is able to dissolve blood clots. This is why nattokinase is now regularly used as a natural blood thinner in the form of a food supplement.
  • You can take nattokinase in either tablet or capsule form, depending on your preference.

The Best Nattokinase: Our Picks

Guide: Questions you should ask yourself before buying nattokinase

What is nattokinase?

Nattokinase is a protein that is an enzyme extracted from the Japanese soybean dish natto . Nattokinase is mainly used in Asia, especially in Japan, and is very popular there.

Nattokinase is basically based on cooked soybeans that are fermented. It was first discovered by a Japanese doctor who had been searching for a natural alternative for thinning the blood for a long time. (Image source: / rawpixel)

Natto is a dish that is over 1000 years old. Its soybeans are cooked and then fermented with certain bacteria. During the process, the bacteria produce the enzyme nattokinase, which consists of 275 amino acids.

The enzyme is said to have fibrinolytic properties in particular. This means that it is able to dissolve blood clots. This is why nattokinase is now regularly used as a natural blood thinner in the form of a food supplement for cardiovascular problems.

What is the effect of nattokinase?

In Germany, the use of nattokinase is not yet really widespread. It is better known as a dietary supplement in the field of alternative medicine. Yet natto is very rich in health-promoting substances such as lecithin, saponins, selenium and vitamin K.

The latter is particularly involved in blood clotting, which is why natto kinase is often treated as a natural blood thinner. In addition to its preventive use against blood clots and the associated high blood pressure, the enzyme generally ensures better blood circulation in the vessels.

Taking nattokinase can help with blood pressure problems. (Image source: / Felipe Santiago Rodriguez Lopez)

This means that all organs are supplied with nutrients more optimally and at the same time metabolic products are better disposed of. This leads to a generally improved performance of body and mind. In the therapy that is already taking place, nattokinase is used directly to reduce blood clotting in order to dissolve the clots.

This reduces the risk of sleep attacks, heart attacks, vascular diseases as well as embolisms. But nattokinase is also used in the treatment of Alzheimer's disease or cancer. Contrary to claims, however, nattokinase is not effective as far as blood fats, such as cholesterol, are concerned.

Who is nattokinase suitable for?

In principle, nattokinase is suitable for anyone who is dependent on blood thinners either as a preventive measure or already for certain reasons. Above all, nattokinase makes sense for you if you want to turn to a natural remedy and not to pharmaceutical drugs.

Nattokinase has been used in Japan for decades for its positive effects on the body, such as lowering blood pressure or protecting against vascular diseases. (Image source: / Tesa Robbins)

Nattokinase is said to help with the following health complaints, among others:

  • Thrombosis
  • High blood pressure
  • Stroke
  • Heart disease
  • Arteriosclerosis
  • Circulatory disorder

What side effects can occur when taking nattokinase?

The intake of nattokinase through food, such as nattokinase, is considered safe. Side effects are not to be expected here. After all, the Japanese dish has been consumed in Japan for several centuries without any problems. As a medical supplement, no side effects are to be expected either, although the current state of knowledge has not yet been sufficiently researched.

There are some indications for certain risk groups that should be considered before taking it.

Risk group Description
People with a blood clotting disorder If you are already taking other blood-thinning medications, it is advisable to avoid taking nattokinase as a supplement. The blood-thinning properties can add up and cause internal bleeding.
Patients before operations Furthermore, it is advantageous to stop taking nattokinase at least one week before upcoming operations. Heavier bleeding during the operation could be the result.
Pregnant women and nursing mothers Pregnant women and nursing mothers are also advised not to take nattokinase for the time being. Unfortunately, there are not enough studies on the possible risks for this risk group.
People with allergies Since nattokinase is derived from a soy product, use should also be avoided if you do not tolerate the allergen soy.

If you still want to try taking nattokinase, please discuss the details with your doctor. Furthermore, it does not hurt to consult a doctor if you are not in one of the risk groups mentioned above. The doctor can adjust the intake and dosage to your individual needs.

How can I take nattokinase?

You can take nattokinase either as a medical food supplement in the form of tablets or capsules. Alternatively, you can eat the Japanese soy dish natto.

How much and how often should I take nattokinase?

Nattokinase is measured in FU, Fibrinolytic Units. According to current research, experts advise not to take more than 2000 FU daily. This dosage is considered safe and effective for most people. Depending on the manufacturer, this can be 1 tablet or capsule or more.

However, the appropriate amount of nattokinase for you depends on different factors, such as age and health status. For this reason, you should always follow the manufacturer's dosage instructions and coordinate the intake and dosage with your doctor or a pharmacist.

How much does nattokinase cost?

The price range of nattokinase preparations depends on the factors quantity and manufacturer. The cheaper versions start at about 10 euros per 100 g, while it can go up to 100 euros per 100 g for the high-priced nattokinase products. The average price is between 40 - 50 euros per 100 g.
price segment price
low-priced from around €10 per 100 g
medium-priced from around €40 per 100 g
high-priced from around €70 per 100 g

It is best to think about how much nattokinase you need for your requirements. Estimate the quantity of the product accordingly when buying it. You can compare the different products based on the price per 100 g.

What alternatives are there to nattokinase?

In addition to natural blood thinners, you can of course use pharmaceutical medicines. The following table shows you an overview of the most common types.
Type Description
Coumarins The best-known drug in Europe is Coumarins, or vitamin K antagonist. Vitamin K is needed for the formation of clotting factors. Coumarins block this vitamin K so that the factors are not formed and the blood becomes thinner.
Heparins Heparins are usually given by injection or infusion. Unlike coumarins, it accelerates the effect of the body's own anticoagulants.
ASS A well-known example of ASS is aspirin for thinning the blood. It inhibits the function of the blood platelets so that they can no longer clump together so easily.

A product that is also obtained from soy is soy protein. This is also an alternative to nattokinase.

Decision: What types of nattokinase are there and which is right for you?

There are no different types of nattokinase as a dietary supplement. The effect of the different preparations is the same after taking them. Nattokinase therefore only differs in the form in which it is administered:

  • Tablet
  • Capsule

In the USA there are now even powders to buy, but these are not yet available in Germany. The different forms of administration each have advantages and disadvantages. Depending on your preference, one or the other form may be suitable for you.

What distinguishes nattokinase as a tablet and what are its advantages and disadvantages?

In the medical field, the well-known dosage form is the tablet. Here, the active ingredient is pressed from powder or granules into a tablet form in individual doses. They are usually taken with water and develop their effect in the stomach.

The advantage of tablets is that they can be taken in exact doses and are easy to take. Most people have seen and taken a tablet before, so at least have difficulty taking it. In addition, most tablets are tasteless, which makes taking them even easier. However, you still need plenty of water for the tablet to reach your stomach. There should be enough water in the stomach so that the tablet can dissolve optimally. Otherwise, the stomach may be strained.

Furthermore, tablets usually have a very long shelf life. You can therefore store them for a long time without worrying and only take them at certain times. Tablets are very reliable in their function, so that the active ingredient reaches where it should.

The body absorbs them very well and quickly because the tablet does not have any additional coating or similar.

  • Easy to take
  • Neutral taste
  • Long shelf life
  • Reliable function
  • A lot of water required
  • Possible strain on the stomach

What makes nattokinase a capsule and what are its advantages and disadvantages?

Capsules are usually taken orally with plenty of water in the same way as tablets. The difference is that capsules consist of a capsule shell and a filling. A distinction is made between hard capsules, which are filled with solid fillings (e.g. powder, granules), and soft capsules, which have liquid or paste fillings.

The shell is usually made of gelatine, rarely also of cellulose or carrageenan. The shell and also the filling are made enteric-coated so that the active ingredient is only released in the intestine and not already in the stomach. This means that the effect lasts longer than with tablets, but at the same time is gentler on the stomach.

A big advantage of capsules is that the active ingredient is protected from external influences such as light. In addition, by breaking open the capsule shell, the active ingredient can be administered in different ways, e.g. in drinks.

On the other hand, capsules require just as much water when taken so that the capsule does not stick to the oesophagus. Furthermore, the capsule does not have as long a shelf life as tablets.

  • Gentle on the stomach
  • Protection of the active ingredient from external influences
  • Combination with other foods or drinks
  • Rarely vegan due to gelatine
  • Longer duration of action
  • Shorter shelf life

Buying criteria: You can use these factors to compare and evaluate nattokinase

In the following we would like to show you which factors you can use to compare and evaluate nattokinase. This will make it easier for you to decide whether a particular nattokinase product is suitable for you or not. In summary, these are:

  • Dosage form
  • Dosage
  • Additives
  • Quality
  • Quantity of the preparation

Dosage form

You can choose between two different forms of nattokinase on the market: Tablets and capsules. Depending on which form of administration is most suitable for you, you should choose this. In the USA, you can now even buy nattokinase powder. However, since this form is not yet available in Germany, we will leave it out.


Most manufacturers dose their tablets or capsules with 2000 FU each. If you are unsure about the dosage, it is best to follow the manufacturer's instructions. You should not exceed the recommendation of 2000 FU nattokinase per day. The possible side effects of an overdose have not yet been adequately researched.


Make sure that your nattokinase preparations are free of unnecessary additives. Most products are offered in pure form. Only the coating of the capsule can consist of various substances. If you want to avoid gelatine, for example, you should pay attention to this when buying.

Some manufacturers also offer nattokinase products that come in combination with other minerals and vitamins. These are said to have additional effects on health. Since there may be interactions, you should consult a doctor first.


When buying a nattokinase preparation, the quality of the product is of course of utmost importance. There are various characteristics that you can use to recognise whether your desired product is a high-quality preparation.

  • The manufacturer openly communicates its quality standards and quality assurance measures.
  • The nattokinase preparation is regularly tested for quality by independent testing or certification bodies.
  • Pay attention to the country of production and the origin of the raw materials so that you can rule out the possibility that harmful substances are involved.
  • The manufacturer declares sufficient information on ingredients, dosage, warnings on side effects, etc.

It is important that you buy a high-quality product. Therefore, it is best to pay attention to the origin of the resources and the country of production. (Picture source: / 1737576)

Quantity of the preparation

Depending on the manufacturer and product, nattokinase is available in different quantities. In online shops, there are numerous offers ranging from manageable quantities to larger stocks.

Therefore, be aware of how much and when you want to take nattokinase. The price ratio of the offers also plays a role in choosing the appropriate amount.

Facts worth knowing about nattokinase

Are there any scientific studies on nattokinase?

Nattokinase is primarily known in the Asian region, especially in Japan. Since it is extracted from a Japanese dish, it is not surprising that a Japanese person discovered this enzyme.

That is why most studies and findings on the effect of nattokinase come from Japan. Since the enzyme is rather unknown in Germany, there are therefore few studies on nattokinase in Europe. The preparation has not yet been well researched in this country.

How can I make nattokinase myself?

Of course you can make the Japanese dish Natto yourself to benefit from the Nattokinase enzyme. To do this, you will need cooked soybeans, the appropriate Natto starter culture and a heat box to maintain the temperature (about 40 degrees) for several hours for fermentation.

Is nattokinase used in animals?

In Germany, Robert Franz is the best-known producer and advocate of nattokinase. He also offers nattokinase capsules for moles and wild boars in his online shop. Unfortunately, there are no sufficient studies or evidence on the effect of nattokinase on animals. Why Robert Franz offers nattokinase exactly for the above-mentioned animals is unfortunately not clear from his site.

Picture source: / Jing

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