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You have heard that papaya enzyme is effective for weight loss problems and mild digestive complaints? But you are not yet convinced of the effect and would like to learn more about the intake, scientific background and necessary criteria for the purchase of papaya enzyme? Then you've come to the right place.

We are pleased that you have found your way to our Papaya Enzyme Test 2021. We will provide you with all the information you need about papaya enzyme. You will not only learn why the plant is said to have healing effects, but also learn something about the plant itself.




The most important facts

  • Papain is a digestive enzyme that occurs naturally in papaya (Carica papaya). It is a protease: an enzyme that breaks down proteins into amino acids, which aids digestion.
  • Papain is extracted from papaya latex, a milky liquid that oozes from the fruit, stem and leaves of the plant. The fruit is richest in papain: the more immature the papaya, the more active the papain.
  • Papain can reduce bloating, flatulence and diarrhoea. According to recent research, it can also fight inflammation and infection.

The Best Papaya Enzyme: Our Picks

Buying and evaluation criteria for papaya enzyme products

When buying lady's mantle, you can pay attention to various aspects, such as:

By making the right choice for you, you can save money and also ensure that you don't give your body anything it doesn't need. Therefore, always look for high quality and, if necessary, ask to see the manufacturer's certificates.

Other ingredients

Some preparations contain other enzymes and ingredients besides papain (i.e. the enzyme) that have a positive additional effect. Most of these substances belong to the group of digestive enzymes.

Caution: Pregnant women should refrain from taking papain. The strong effect against parasites could cause damage to the child and its not yet fully grown gastrointestinal tract. The ripe flesh of the papaya can be consumed without hesitation.

Bromelain and papain are often mentioned in the same breath because they both come from tropical fruits and have similar positive effects.

Bromelain enzymes, which come from the pineapple, are used for swelling after injuries and operations. It also belongs to the digestive enzyme type and thus promotes metabolism in a similar way to papain.

Form of administration

Unripe papayas contain papain, but it is difficult to say how much. For a more precise dosage, papaya enzyme is available as fruit pulp/puree, powder, capsules, chewable tablets and lozenges.

Papaya enzyme products as food supplements are available in the form of chewable tablets or capsules with the powder extract. The chewable tablets are easy to take and usually taste pleasantly fruity. The powder from the capsule can either be taken directly orally or stirred into milkshakes or yoghurt and consumed.

Depending on your health goals, you can take the papaya enzyme by mouth or apply it to your skin. Accordingly, it is also available in creams, gels and wound dressings.

Dosage

Generally speaking, the papaya enzyme is in a higher dosage in the capsules than in the chewable tablets. The chewable tablets usually contain only 100 mg or 200 mg of papaya enzyme. The normal dosage for the capsules, on the other hand, is 400 mg papaya enzyme per capsule.

Experts generally recommend 400 mg of papaya enzyme per day to positively enhance weight loss. This means one capsule of 400 mg or 4 chewable tablets of 100 mg papaya enzyme. To achieve a wound-healing effect, three to four times this amount is needed.

Basically, this is a natural preparation and not a chemical. Therefore, serious side effects and cross reactions are extremely rare. Nevertheless, you should not take more than 2000 milligrams a day. Otherwise, you may develop throat disorders or allergic reactions.

Package size

You can often buy capsules in particular in large stock packs. This also means a lower (extrapolated) price. However, if you want to try the product first, we advise you to buy a smaller pack so as not to waste too much.

The shelf life of the products can also differ. If you only want to take papain infrequently, a particularly large pack is not necessarily advisable. Capsules usually have a shelf life of two years. Other dosage forms often have a shorter shelf life.

Guide: Frequently asked questions on the subject of papaya enzyme products answered in detail

In order to inform you comprehensively about the effectiveness of lady's mantle and to give you an understanding of the current state of science, we have summarised all the important information in the following sections.

What is papaya enzyme?

Papaya enzyme is a digestive enzyme that occurs naturally in papaya (Carica papaya). It is a protease: an enzyme that breaks down proteins into amino acids, which aids digestion. (1) .

Papain is extracted from papaya latex, a milky liquid that oozes from the fruit, stem and leaves of the plant. The fruit is richest in papain: the more immature the papaya, the more active the papain (2, 3).

Papaya Enzym-1

The green, still unripe papayas contain up to 5000 % more papain than the ripe ones
(Image source: wengang zhai / unsplash)

People have long known about the papaya enzyme, which they use to improve digestion and relieve pain, swelling and inflammation. Papain can reduce bloating, flatulence and diarrhoea. According to recent research, it can also fight inflammation and infection (4, 5, 6).

You can get papaya enzymes by eating papayas ... but you would have to eat a lot of mostly unripe fruit. You can recognise unripe papayas by the green colour of their skin. Alternatively, various papaya enzyme supplements are widely available (7).

How does the papaya enzyme work?

Improves digestion

Overall, papaya enzyme aids digestion by breaking down proteins into amino acids, which helps the body absorb nutrients. Therefore, it can improve symptoms in people with various digestive disorders (8, 9).

  • Coeliac disease: Papain can break down parts of gliadin, a component of gluten. As such, it has the potential to help people with celiac disease. In 3 people with celiac disease, papain supplements improved nutrient absorption and reduced loose stools (10, 11).
  • Indigestion & heartburn: In a clinical trial of 200 people with indigestion, papain reduced stomach inflammation. Compared to placebo, it relieved symptoms such as stomach pain, vomiting, nausea, heartburn, belching and flatulence (12).
  • Irritable bowel syndrome: In two clinical trials with a total of over 150 people suffering from either constipation-dominant irritable bowel syndrome or chronic gastritis, papaya enzyme improved symptoms such as constipation, bloating, painful bowel movements, flatulence and stomach pain while reducing inflammation. Papaya enzyme can also block the growth of harmful gut bacteria that cause IBS and other stomach and intestinal disorders (13).
  • Stomach ulcers: papain also reduced stomach acidity and ulcer size in rats with stomach ulcers (14).

All in all, the evidence suggests that papain can help with digestive problems such as indigestion, irritable bowel syndrome and stomach inflammation. You can discuss with your doctor whether it can help as an addition to your treatment regime.

Important: Never use papain as a substitute for what your doctor recommends or prescribes.

Papaya Enzym-2

Taken daily, papain can help break down food and provide a cheery start to the day.
(Image source: brooke cagle / unsplash)

The papaya enzyme can improve digestion, gut flora and nutrient absorption in people with coeliac disease, indigestion and irritable bowel syndrome. It may also protect against stomach ulcers.

Wound healing

In several clinical studies involving over 350 people and 30 children, papaya enzyme applied to the skin accelerated the healing of skin ulcers or burns (15, 16, 17).

It reduced wound size, removed damaged tissue, accelerated wound closure and shortened hospital stay. It worked better than collagenase, hydrogen peroxide dressing or placebo (15, 16, 17).

In animal and cell-based studies, topical papain removed dead cells and tissue, stimulated wound healing and reduced scarring and inflammation. Apart from promoting the formation of new tissue, it can also prevent bacterial infections(18, 19).

Again, the available evidence supports the use of papain for wound healing. You can use it for this purpose if your doctor determines that it may be helpful in your case.

When and for whom is it useful to take papaya enzyme?

Papaya enzyme is mostly aimed at overweight people who suffer from complaints and symptoms related to obesity or metabolism.

However, papaya enzyme does not only have to be taken during acute complaints, but you can also take papaya enzyme long-term and thus prophylactically.

These are the classic complaints or areas of application that are treated with papaya enzyme in naturopathy, although there is not clear scientific evidence for everything:

  • It can help relieve sore throats
  • It can relieve pain and inflammation
  • It aids digestion
  • It helps heal wounds
  • It relieves sore muscles
  • It can help relieve shingles symptoms

Which parts of the plant are processed for papaya enzyme?

Unfortunately, the papaya enzyme from the delicious flesh of the papaya only occurs in very small quantities. Much more of the healthy papain is contained in the still unripe, green fruits. Here it is mainly found in the seeds and skin of the papaya.

This is why the enzyme is usually offered as a preparation in higher doses and in concentrated form. For this purpose, papain is mainly extracted from the Carica papaya, the melon tree.

How much does papaya enzyme cost?

During our research, we found out that the prices for papaya enzyme can vary greatly depending on the dosage form. For better comparability, we have compiled a price overview that shows the price per packaging unit:

Dosage form Price
Papaya enzyme tablets c.a. 12 € - 25 €
Papaya Enzyme Capsules c. a. 12 € - 54 €

The most expensive are highly concentrated capsule preparations enriched with papaya enzyme. There are also capsules that go far beyond a 400 mg dosage and contain up to 1500 mg of papaya enzyme.

You can usually get tablets and capsules in packages of between 100 and 120.

What types of papaya enzymes are there?

Since papaya enzymes are extracted from papaya, they are usually first processed before they can be taken in effective quantities. Therefore, the preparations containing papaya enzymes differ in their dosage form.

Basically, a distinction can be made between these two (most widespread) types:

Dosage form Price
Papaya enzyme tablets lower dosage often together with other contents that are supposed to have a weight-loss-promoting effect
Papaya Enzyme Capsules Highly concentrated units. Also suitable for external use to treat wounds.

We will explain the advantages and disadvantages of both variants in more detail in the next few paragraphs.

Papaya enzyme tablets

Some preparations contain other enzymes and ingredients besides papain that have a positive additional effect. Most of these substances belong to the group of digestive enzymes. A selection of additional substances that you usually find in chewable tablets are:

  • Bromelain: by far the most popular combination. Bromelain can also improve digestion and reduce inflammation. In addition, a toothpaste with papain and bromelain stains the teeth better than a regular toothpaste in the lab (20).
  • Other digestive enzymes: Mult i-enzyme formulas can further improve digestion. Sometimes probiotics and/or bile are also added (21).

Chewable tablets are particularly easy to take. They are often made with papaya flavouring to taste fruity and delicious.

Papaya Enzyme Capsules

If you don't have a problem swallowing or chewing larger tablets, then papaya enzyme capsules are for you. Because the contents of the capsule are coated from the outside, the capsule does not have a taste of its own and therefore makes it easier to take.

You can take the capsule content either directly or by mixing it into food and drink.

Many manufacturers combine papaya enzyme with other herbal remedies in their capsules, which means that you can do without other remedies and only need to take one type of capsule.

Capsules have the advantage that a high dosage of the active ingredients is possible. In addition, the capsules are usually available in very large storage packs, so you are covered for several weeks.

If you value vegan products, not every capsule may be suitable for you. Sometimes the shells are made from animal ingredients.

How should the papaya enzyme be dosed?

The appropriate dosage for you depends on the reason for taking it. If you want to lose weight, 400 mg of papain per day is sufficient; if you want to fight an infection, it should be three times that amount. Then you can decide how strong the capsules or tablets should be.

Papaya Enzym-3

The amount taken should not exceed 2000 mg per day
(Image source: eugenivy reserv / unsplash)

Among the many choices, you can find pure papain preparations as well as those that contain other enzymes or supplements. These are much lower in papain dosage. Lower daily doses are also recommended here, as the other substances are dosed differently.

In addition, enzyme complexes often aim to increase general well-being rather than a specific therapy.

What alternatives are there to papaya enzyme?

If you are looking for other enzymes that contribute to weight reduction, you may find them in the following alternatives:

enzyme effect effect
Bromelain Digests proteins Improves metabolism and helps against inflammation
Amylase breaks down starch and carbohydrates improves digestion
Protease breaks down proteins helps with food allergies and improves digestion
Lipase breaks down fats relieves the gallbladder, liver and pancreas
Cellulase breaks down fibres increases the nutritional value of fruits and vegetables
Maltase breaks down sugar ensures smooth functioning and maintenance of muscles

Papaya as a fruit is also considered very healthy.

Can I get sufficient amounts of papaya enzyme by eating papayas?

Papain is present in the papaya fruit, but large amounts, such as those contained in a capsule or in tablet form, are far from it. You would have to eat tens of kilos of it every day to get a sufficient supply of this valuable enzyme. Basically, however, papaya is a very healthy fruit.

Since green, unripe papayas contain almost 5,000 percent more papain than a ripe fruit, a green papaya salad, as it is prepared in tropical countries, is very healthy.

However, to get the positive effect of papaya enzymes you need to choose more concentrated capsules or tablets.

Image source: Turshina / 123rf

References (21)

1. Amri, E. & Mamboya, F. (2012). Papain, a Plant Enzyme of Biological Importance: A Review. American Journal of Biochemistry and Biotechnology, 8(2), 99-104.
Source

2. Baines, B. S., & Brocklehurst, K. (1979). A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods. The Biochemical journal, 177(2), 541–548.
Source

3. KIMMEL JR, SMITH EL. The properties of papain. Adv Enzymol Relat Subj Biochem. 1957;19:267-334.
Source

4. Weiser FA, Fangl M, Mosgoeller W. Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain. Neuro Endocrinol Lett. 2018 Mar;39(1):19-25. PMID: 29604620.
Source

5. Pandey S, Cabot PJ, Shaw PN, Hewavitharana AK. Anti-inflammatory and immunomodulatory properties of Carica papaya. J Immunotoxicol. 2016 Jul;13
Source

6. Nguyen TT, Shaw PN, Parat MO, Hewavitharana AK. Anticancer activity of Carica papaya: a review. Mol Nutr Food Res. 2013 Jan;57
Source

7. Muss C, Mosgoeller W, Endler T. Papaya preparation (Caricol®) in digestive disorders. Neuro Endocrinol Lett. 2013
Source

8. Gabriela Cáez Ramírez, Darío Iker Téllez-Medina, Evangelina García-Armenta, Gustavo Fidel Gutiérrez -López. (2017) Digital image analysis and fractal metrics as potential tools to monitor colour changes in fresh-cut papaya (Carica papaya L.). International Journal of Food Properties 20:sup1, pages S177-S189.
Source

9. MESSER M, ANDERSON CM, HUBBARD L. STUDIES ON THE MECHANISM OF DESTRUCTION OF THE TOXIC ACTION OF WHEAT GLUTEN IN COELIAC DISEASE BY CRUDE PAPAIN. Gut. 1964 Aug;5
Source

10. Messer M, Baume PE. Oral papain in gluten intolerance. Lancet. 1976 Nov 6
Source

11. Li Y, Yu J, Goktepe I, Ahmedna M. The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour. Food Chem. 2016 Apr 1
Source

12. Ahmad, M., Ahmad, M., & Munir, T. (2018). Prevention of Functional Dyspepsia with Carica Papaya Extract. Annals of King Edward Medical University, 24(
Source

13. da Silva CR, Oliveira MB, Motta ES, de Almeida GS, Varanda LL, de Pádula M, Leitão AC, Caldeira-de-Araújo A. Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papaya L.) Using In Vitro Assays. J Biomed Biotechnol. 2010;2010:197898. doi: 10.1155/2010/197898. Epub 2010 May 20.
Source

14. Indran M, Mahmood AA, Kuppusamy UR. Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Med J. 2008 Sep
Source

15. Murthy, M. B., Murthy, B. K., & Bhave, S. (2012). Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape. Indian journal of pharmacology
Source

16. Starley IF, Mohammed P, Schneider G, Bickler SW. The treatment of paediatric burns using topical papaya. Burns. 1999 Nov
Source

17. Pieper B, Caliri MH. Nontraditional wound care: A review of the evidence for the use of sugar, papaya/papain, and fatty acids. J Wound Ostomy Continence Nurs. 2003 Jul
Source

18. Karski J, Wolski T, Skublewski K, Wolski J, Karski M. The use of vegetable proteolytic enzymes in the treatment of surgical diseases. Ann Univ Mariae Curie Sklodowska Med. 1994
Source

19. Hewitt H, Whittle S, Lopez S, Bailey E, Weaver S. Topical use of papaya in chronic skin ulcer therapy in Jamaica. West Indian Med J. 2000 Mar
Source

20. Kalyana P, Shashidhar A, Meghashyam B, Sreevidya KR, Sweta S. Stain removal efficacy of a novel dentifrice containing papain and Bromelain extracts--an in vitro study. Int J Dent Hyg. 2011 Aug
Source

21. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A., & Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current drug metabolism
Source

Why you can trust me?

Wissenschaftlicher Review
Amri, E. & Mamboya, F. (2012). Papain, a Plant Enzyme of Biological Importance: A Review. American Journal of Biochemistry and Biotechnology, 8(2), 99-104.
Go to source
Wissenschaftlicher Review
Baines, B. S., & Brocklehurst, K. (1979). A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods. The Biochemical journal, 177(2), 541–548.
Go to source
Wissenschaftlicher Review
KIMMEL JR, SMITH EL. The properties of papain. Adv Enzymol Relat Subj Biochem. 1957;19:267-334.
Go to source
Wissenschaftliche Studie
Weiser FA, Fangl M, Mosgoeller W. Supplementation of Caricol®-Gastro reduces chronic gastritis disease associated pain. Neuro Endocrinol Lett. 2018 Mar;39(1):19-25. PMID: 29604620.
Go to source
Wissenschaftlicher Review
Pandey S, Cabot PJ, Shaw PN, Hewavitharana AK. Anti-inflammatory and immunomodulatory properties of Carica papaya. J Immunotoxicol. 2016 Jul;13
Go to source
Wissenschaftlicher Review
Nguyen TT, Shaw PN, Parat MO, Hewavitharana AK. Anticancer activity of Carica papaya: a review. Mol Nutr Food Res. 2013 Jan;57
Go to source
Wissenschaftliche Studie
Muss C, Mosgoeller W, Endler T. Papaya preparation (Caricol®) in digestive disorders. Neuro Endocrinol Lett. 2013
Go to source
Wissenschaftlicher Review
Gabriela Cáez Ramírez, Darío Iker Téllez-Medina, Evangelina García-Armenta, Gustavo Fidel Gutiérrez -López. (2017) Digital image analysis and fractal metrics as potential tools to monitor colour changes in fresh-cut papaya (Carica papaya L.). International Journal of Food Properties 20:sup1, pages S177-S189.
Go to source
Wissenschaftlicher Review
MESSER M, ANDERSON CM, HUBBARD L. STUDIES ON THE MECHANISM OF DESTRUCTION OF THE TOXIC ACTION OF WHEAT GLUTEN IN COELIAC DISEASE BY CRUDE PAPAIN. Gut. 1964 Aug;5
Go to source
Wissenschaftlicher Review
Messer M, Baume PE. Oral papain in gluten intolerance. Lancet. 1976 Nov 6
Go to source
Wissenschaftlicher Review
Li Y, Yu J, Goktepe I, Ahmedna M. The potential of papain and alcalase enzymes and process optimizations to reduce allergenic gliadins in wheat flour. Food Chem. 2016 Apr 1
Go to source
Wissenschaftliche Studie
Ahmad, M., Ahmad, M., & Munir, T. (2018). Prevention of Functional Dyspepsia with Carica Papaya Extract. Annals of King Edward Medical University, 24(
Go to source
Wissenschaftliche Studie
da Silva CR, Oliveira MB, Motta ES, de Almeida GS, Varanda LL, de Pádula M, Leitão AC, Caldeira-de-Araújo A. Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papaya L.) Using In Vitro Assays. J Biomed Biotechnol. 2010;2010:197898. doi: 10.1155/2010/197898. Epub 2010 May 20.
Go to source
Wissenschaftliche Studie
Indran M, Mahmood AA, Kuppusamy UR. Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Med J. 2008 Sep
Go to source
Wissenschaftlicher Review
Murthy, M. B., Murthy, B. K., & Bhave, S. (2012). Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape. Indian journal of pharmacology
Go to source
Wissenschaftliche Studie
Starley IF, Mohammed P, Schneider G, Bickler SW. The treatment of paediatric burns using topical papaya. Burns. 1999 Nov
Go to source
Wissenschaftliche Studie
Pieper B, Caliri MH. Nontraditional wound care: A review of the evidence for the use of sugar, papaya/papain, and fatty acids. J Wound Ostomy Continence Nurs. 2003 Jul
Go to source
Wissenschaftlicher Review
Karski J, Wolski T, Skublewski K, Wolski J, Karski M. The use of vegetable proteolytic enzymes in the treatment of surgical diseases. Ann Univ Mariae Curie Sklodowska Med. 1994
Go to source
Wissenschaftliche Studie
Hewitt H, Whittle S, Lopez S, Bailey E, Weaver S. Topical use of papaya in chronic skin ulcer therapy in Jamaica. West Indian Med J. 2000 Mar
Go to source
Wissenschaftliche Studie
Kalyana P, Shashidhar A, Meghashyam B, Sreevidya KR, Sweta S. Stain removal efficacy of a novel dentifrice containing papain and Bromelain extracts--an in vitro study. Int J Dent Hyg. 2011 Aug
Go to source
Wissenschaftlicher Review
Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A., & Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current drug metabolism
Go to source
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