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Are you overweight and neither exercise nor a strict diet can help you lose weight? Then the dietary supplement phentramine could be an option for you. In our phentramine test 2021 we present phentramine, its mode of action and its side effects clearly based on scientific studies.

This way you can form your own opinion about phentramine. We also tell you how to take phentramine, where you can buy it, who phentramine is not suitable for and what alternatives there are.




The most important facts

  • Phentramine is a prescription drug that is taken over a short period of time to lose weight. Phentramine has not been available in Germany since the 1970s.
  • Phentramine is prescribed to people with a BMI (body mass index) of 30 who do not lose weight despite an active lifestyle and a calorie-reduced diet.
  • Phentramine is available in capsule and tablet form. Side effects can include dry mouth, constipation, insomnia, nervousness, cardiovascular disorders and high blood pressure.

The Best Phentramine: Our Picks

Buying and evaluation criteria for phentramine

Phentramine products differ with regard to the following properties:

In the following, we go into more detail about the individual purchase and evaluation criteria and tell you what you should look out for when taking phentramine.

Dosage form

Phentramine is available both as a tablet and as a capsule. Both dosage forms have their advantages and disadvantages.

Phentramine is available as capsules and tablets.

If you don't like taking tablets, you should take capsules. The coating makes them easier to swallow. The capsule also protects the active ingredient from stomach acid, so it can fully develop.

If you have no problem taking tablets, you can opt for this cheaper alternative. However, phentramine in tablet form can still affect your digestive tract.

Dosage

Phentramine is available in the following dosages: 8 mg, 15 mg, 30 mg, 37.5 mg.

Your doctor must determine the correct dosage. You should stick to this dosage and neither exceed nor fall below it. This is the only way to achieve the desired effect.

Stronger doses of phentramine (15-37.5 mg) should be taken once a day 1 hour before breakfast. Alternatively, you can take them 1-2 hours after breakfast. Lower doses (8 mg) are usually taken three times a day 30 minutes before a meal.

Other ingredients

Pure phentramine products are rather rare, as humans have built up a tolerance to the substance after about 12 weeks. Therefore, other ingredients are added to prolong or enhance the effect. The following substances may be included:

  • Caffeine
  • Tyrosine
  • Naringin
  • Tryptophan

You should check the ingredients carefully. You should be able to tolerate these.

Guide: Frequently asked questions about phentramine answered in detail

In order to provide you with sufficient information about phentramine and its mode of action, we have compiled the most important information, including scientific studies, in the following paragraphs.

What is phentramine?

Phentramine has been used in the USA since 1959 to treat chronic overweight and obesity. At the same time, the risk of developing diabetes and high blood pressure can be reduced (1, 2).

Phentramine is a dietary supplement that stimulates the nervous system. It is used in the USA to treat obesity. (Image source: i Yunmai / unsplash)

Phentramine is a prescription drug in the USA. In Germany, phentramine has not been approved since the 1970s because it has had a negative effect on heart valves. Since 2012, phentramine has been used in the USA in combination with topiramate as an appetite suppressant for the treatment of obesity. This is also not permitted in Germany because the risk of this drug is estimated to be higher than its benefit (1).

Phentramine falls under the category of stimulants. A stimulant improves or increases nerve function. Phentramine is more precisely an amphetamine-like substance. It has a very invigorating and euphoric effect and stimulates the nervous system. Pure phentramine products are rare. Often, several active substances are combined to achieve better results.

The table gives you an overview of the substances that can be contained.

Active ingredient Mode of action
Caffeine Caffeine is probably the best-known stimulant. It can invigorate the body, improve the function of the nervous system and suppress the feeling of hunger for a short time. It can also improve fat breakdown, meaning more fat is burned (3).
Tyrosine Tyrosine is an amino acid that positively influences the production of dopamine. Dopamine is often referred to as the "happy hormone". Tyrosine can reduce stress and increase well-being. If you suffer from concentration problems during your diet, tyrosine can help you (4, 5, 6).
Naringin Naringin is a bitter substance that can reduce appetite. Furthermore, naringin increases the potency of stimulants. This means that the body burns more calories (7).
Tryptophan Tryptophan is an amino acid that increases serotonin levels. This reduces stress and lifts your mood. It can also have a positive effect on your sleep and inner peace (8).

You cannot get pure phentramine from certain foods, unlike some of the substances listed above that may be present in phentramine products. Phentramine intake must be obtained by taking phentramine products.

How does phentramine work?

Phentramine affects the neurotransmitters in your brain by activating the neuron bundles. As a result, substances such as adrenaline, noradrenaline and dopamine are released. These stimulate the metabolism and suppress the feeling of hunger. In other words, you eat less because your feeling of fullness lasts longer. Phentramine can work in the following ways:

  • weight-reducing
  • stimulates fat burning
  • appetite suppressing
  • Counteracting secondary diseases

In the following, we explain the effects in more detail based on studies.

Weight-reducing

Phentramine can have a weight-reducing effect. A study from Korea shows that taking pure phentramine can lead to weight loss and a smaller waist circumference in overweight patients (9).

Phentramine can have weight-reducing, fat-burning and appetite-suppressing effects, among others. A study shows that phentramine can reduce waist circumference. (Image source: Siora Photography / unsplash)

Other studies investigated the effect of phentramine in combination with topiramate. The results confirmed that this drug can reduce body weight in overweight adults. Long-term studies are desired, as side effects may occur (1, 10).

Increased fat burning

Phentramine can increase fat burning and thus lead to faster weight loss. The Korean study proves this. Subjects treated with phentramine achieved greater success in losing weight than the placebo group (9).

Appetite suppressant

The feeling of hunger can be a big problem when losing weight. Studies have shown that phentramine can suppress the feeling of hunger. Patient groups treated with phentramine clearly feel less hunger than the placebo groups (9, 11).

Counteracts secondary diseases

Common secondary diseases of obesity can be high blood pressure, high cholesterol or diabetes. Studies show that phentramine can also have a positive effect on these conditions. Systolic blood pressure as well as cholesterol-triglyceride and glucose levels could be lowered.

It can therefore be concluded that phentramine, in addition to its weight-reducing effects, can also lower blood pressure and cholesterol levels and reduce the risk of developing diabetes (1, 2). However, another study has shown that sympathomimetics, of which phentramine is one, can increase blood pressure (12).

When and for whom is it useful to take phentramine?

Phentramine is used for a short period (max. 12 weeks) in overweight people for whom a calorie-reduced diet and an active lifestyle are not sufficient to lose weight.

Overweight people are treated with phentramine if no weight loss success is achieved despite an active lifestyle and calorie-reduced diet. Nevertheless, phentramine is only a dietary supplement and cannot replace exercise or a diet. (Image source: Thought Catalog / unsplash)

Phentramine is mainly prescribed to overweight people with a BMI of 30 or more. In some cases, people with a BMI of 27 are treated with phentramine if they suffer from obesity-related diseases. These include high blood pressure, diabetes and high cholesterol.

However, phentramine alone is not enough to reduce your weight. During your treatment with phentramine, you still need to exercise a lot and watch what you eat. Taking phentramine is not a substitute for exercise or diet.

How should I take phentermine?

Depending on the combination product, you should follow the manufacturer's recommendations.
Phentramine should be taken 1-3 times a day before a meal.

Basically, you should take phentramine (15-37.5 mg) once a day before breakfast. This way, the feeling of hunger is curbed immediately and an appetite-suppressing result can be achieved, as you already eat less at breakfast. With lower-dose products (8 mg), phentramine can be taken three times a day 30 minutes before a meal.

Phentramine should be taken for a maximum of 12 weeks. The effect wears off over time because people build up a tolerance to the substance. Phentramine in combination with other ingredients can be taken for longer. The additional substances can enhance and prolong the effect.

What types of phentermine are available?

Phentramine is available in both capsule and tablet form. Below we explain the advantages and disadvantages of both types.

Capsule

Phentramine in capsule form is easier to dose and more pleasant to swallow because of its smooth surface. In addition, the capsule serves as protection against stomach acid and unpleasant tastes. Thus, the active ingredient is better protected and the digestive tract is not affected.

Advantages
  • Easy to dose
  • No impairment of the digestive tract
  • Active ingredient is better protected
Disadvantages
  • More expensive
  • Side effects

Phentramine in capsule form is the higher quality version and therefore more expensive. However, if you want the best possible results, we recommend capsules made from cellulose or gelatine.

Tablet

Phentramine in tablet form is the cheaper alternative. This is because it is easy to produce. The substance is available in powder form and is pressed with other excipients into a tablet without coating.

Advantages
  • Cheaper
Disadvantages
  • Impairment of the digestive tract
  • swallowing the rough tablet
  • side effects

Disadvantages may be that the excipients can negatively affect the digestive tract. In addition, people may find it difficult to swallow the rough tablets without a coating.

What are the side effects of taking phentramine?

Taking phentramine can of course lead to side effects. The most commonly documented ones include:

  • Dry mouth
  • Constipation
  • lightheadedness
  • Insomnia
  • Nervousness
  • Cardiovascular disorders
  • High blood pressure
  • Paraesthesia (abnormal body sensation)
  • Taste disorders (1, 9, 10, 12)

Higher dosages are more likely to cause depression or anxiety disorders. This suggests that lower dosages are better tolerated (10).

Who should not take phentramine?

Stimulants, including phentramine, stimulate the metabolism, which can increase the pulse rate and blood pressure (12).

Therefore, people with high blood pressure should not be treated with phentramine.

Furthermore, phentramine is not suitable for pregnant women, people with cardiovascular diseases and a history of drug abuse (13). Children should also not take phentramine.

What alternatives are there to phentramine?

Since phentramine is no longer on the market in Germany, we have listed 2 alternatives below that can also help you lose weight.

Alternative Mode of action
Green tea Green tea boosts fat burning and is therefore a good aid to losing weight. In addition, the bitter substances curb cravings (14). Instead of drinking green tea, you can also take the extract in capsule form.
Green coffee beans Green coffee beans are unroasted coffee beans. The extract is also available in capsules. It can help with weight loss by reducing body fat (15).

It is best to consult your doctor. He or she can help you decide between the active ingredients.

Image source: morganka / 123rf

References (15)

1. Siebenhofer A, Jeitler K, Horvath K, et al. Long-term effects of weight-reducing drugs in people with hypertension. Cochrane Database Syst Rev. 2016;3:CD007654. Published 2016 Mar 2. doi:10.1002/14651858.CD007654.pub4
Source

2. Chukir T, Shukla AP, Saunders KH, Aronne LJ. Pharmacotherapy for obesity in individuals with type 2 diabetes. Expert Opin Pharmacother. 2018;19(3):223-231. doi:10.1080/14656566.2018.1428558
Source

3. Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jéquier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr. 1980;33(5):989-997. doi:10.1093/ajcn/33.5.989
Source

4. Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999;48(2):203-209. doi:10.1016/s0361-9230(98)00163-4
Source

5. Shurtleff D, Thomas JR, Schrot J, Kowalski K, Harford R. Tyrosine reverses a cold-induced working memory deficit in humans. Pharmacol Biochem Behav. 1994;47(4):935-941. doi:10.1016/0091-3057(94)90299-2
Source

6. Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989;22(4):759-762. doi:10.1016/0361-9230(89)90096-8
Source

7. Stohs SJ, Preuss HG, Keith SC, Keith PL, Miller H, Kaats GR. Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes. Int J Med Sci 2011; 8(4):295-301. doi:10.7150/ijms.8.295
Source

8. Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009;2:45-60. doi:10.4137/ijtr.s2129
Source

9. Kim KK, Cho HJ, Kang HC, Youn BB, Lee KR. Effects on weight reduction and safety of short-term phentermine administration in Korean obese people. Yonsei Med J. 2006;47(5):614-625. doi:10.3349/ymj.2006.47.5.614
Source

10. Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet (London, England). 2011 Apr;377(9774):1341-1352. DOI: 10.1016/s0140-6736(11)60205-5
Source

11. Weight Loss Agents. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; June 5, 2020.
Source

12. Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311(1):74-86. doi:10.1001/jama.2013.281361
Source

13. In brief: Phentermine (Lomaira) for weight loss. Med Lett Drugs Ther. 2016;58(1509):158.
Source

14. Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010;5:13. Published 2010 Apr 6. doi:10.1186/1749-8546-5-13
Source

15. Bong-Keun Choi, Sung-Bum Park, Dong-Ryung Lee, Hae Jin Lee, Ying-Yu Jin, Seung Hwan Yang, Joo-Won Suh. Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pacific Journal of Tropical Medicin. 2016;9:7, 635-643. https://doi.org/10.1016/j.apjtm.2016.05.017
Source

Why you can trust me?

Wissenschaftlicher Artikel
Siebenhofer A, Jeitler K, Horvath K, et al. Long-term effects of weight-reducing drugs in people with hypertension. Cochrane Database Syst Rev. 2016;3:CD007654. Published 2016 Mar 2. doi:10.1002/14651858.CD007654.pub4
Go to source
Wissenschaftlicher Artikel
Chukir T, Shukla AP, Saunders KH, Aronne LJ. Pharmacotherapy for obesity in individuals with type 2 diabetes. Expert Opin Pharmacother. 2018;19(3):223-231. doi:10.1080/14656566.2018.1428558
Go to source
Klinische Studie
Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jéquier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr. 1980;33(5):989-997. doi:10.1093/ajcn/33.5.989
Go to source
Klinische Studie
Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999;48(2):203-209. doi:10.1016/s0361-9230(98)00163-4
Go to source
Klinische Studie
Shurtleff D, Thomas JR, Schrot J, Kowalski K, Harford R. Tyrosine reverses a cold-induced working memory deficit in humans. Pharmacol Biochem Behav. 1994;47(4):935-941. doi:10.1016/0091-3057(94)90299-2
Go to source
Klinische Studie
Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989;22(4):759-762. doi:10.1016/0361-9230(89)90096-8
Go to source
Klinische Studie
Stohs SJ, Preuss HG, Keith SC, Keith PL, Miller H, Kaats GR. Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes. Int J Med Sci 2011; 8(4):295-301. doi:10.7150/ijms.8.295
Go to source
Wissenschaftlicher Artikel
Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. 2009;2:45-60. doi:10.4137/ijtr.s2129
Go to source
Klinische Studie
Kim KK, Cho HJ, Kang HC, Youn BB, Lee KR. Effects on weight reduction and safety of short-term phentermine administration in Korean obese people. Yonsei Med J. 2006;47(5):614-625. doi:10.3349/ymj.2006.47.5.614
Go to source
Klinische Studie
Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet (London, England). 2011 Apr;377(9774):1341-1352. DOI: 10.1016/s0140-6736(11)60205-5
Go to source
Wissenschaftlicher Artikel
Weight Loss Agents. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; June 5, 2020.
Go to source
Klinische Studie
Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014;311(1):74-86. doi:10.1001/jama.2013.281361
Go to source
Wissenschaftlicher Artikel
In brief: Phentermine (Lomaira) for weight loss. Med Lett Drugs Ther. 2016;58(1509):158.
Go to source
Wissenschaftlicher Artikel
Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010;5:13. Published 2010 Apr 6. doi:10.1186/1749-8546-5-13
Go to source
Wissenschaftliche Untersuchung
Bong-Keun Choi, Sung-Bum Park, Dong-Ryung Lee, Hae Jin Lee, Ying-Yu Jin, Seung Hwan Yang, Joo-Won Suh. Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pacific Journal of Tropical Medicin. 2016;9:7, 635-643. https://doi.org/10.1016/j.apjtm.2016.05.017
Go to source
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