Last updated: August 11, 2021

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In this article we want to introduce you to Saccharomyces boulardii. This tongue twister is a so-called probiotic, i.e. an extremely useful yeast fungus. This fungus works exclusively in the intestine and can support and stabilise the intestinal flora there.

In our Saccharomyces boulardii test 2021 you will find the best products with this active ingredient. We have also explained the most important purchase criteria and answered the most frequently asked questions.




The most important facts

  • Saccharomyces boulardii (also called Saccharomyces cerevisiae Hansen CBS-5926) is an approved medicinal yeast and contains live microorganisms. It is not to be confused with brewer's yeast or yeast for baking.
  • The microorganisms work exclusively in the intestines. They fight bacteria there and can help stabilise the intestinal flora. This alleviates acute diarrhoea or diarrhoea caused by antibiotics. But Saccharomyces boulardii can also help in the treatment of acne.
  • Saccharomyces boulardii belongs to the probiotics. There are many preparations that contain a number of probiotic active ingredients. But fermented foods such as sauerkraut also contain probiotics that can have a positive effect on the body.

The Best Saccharomyces Boulardii: Our Picks

Buying and evaluation criteria for Saccharomyces boulardii

When buying Saccharomyces boulardii, you can pay attention to various aspects, such as:

By making the right choice for you, you can save money and also ensure that you do not give your body anything it does not need. Therefore, always pay attention to high quality and any additives.

Form of intake

There are different ways to take Saccharomyces boulardii. There used to be more different forms, but capsules and powders have become more common. It is important to take it before meals. This allows the yeast fungus to enter the intestine unhindered.

Capsules

These pills usually contain Saccharomyces boulardii as a powder in an enteric-coated capsule. These capsules are available in different materials. It is worth looking more closely at the ingredients in this form. They can contain various additives (we will take a closer look at which ones in our guide).

Powder

The powder is usually pre-packed in individual sachets.

The form in which it is taken has no influence on its effectiveness.

Loose powder should be dosed with a suitable measuring cup. Capsules are somewhat more practical to use, but the powder is particularly suitable for people with swallowing difficulties and for children.

We will explain the advantages and disadvantages of each form in more detail in the guide.

Dosage

The dosage is individual, depending on the purpose of use, the way it is taken and also body size.

As a rule, the recommended amount is between 250 mg and 750 mg.

Saccharomyces boulardii is suitable for children from the age of two. Care should be taken that the total dose, as well as the individual doses, are not so high. A well-known manufacturer of Saccharomyces boulardii gives the following information as a guideline for adults.

Intended use Dosage Duration
Acute diarrhoea 250 - 500 mg Until symptoms are over
Prevention of travellers' diarrhoea 250 - 500 mg Until after the journey and up to 5 days before the start of the journey
Acne 500 - 750 mg Until symptoms are less or gone

There is no official maximum length of time that yeast can be taken. If in doubt, consult your doctor or pharmacist.

Tolerance

If no other ingredients are added, the drug Saccharomyces boulardii is tolerated by most people without any problems. In rare cases, the ingestion leads to slight flatulence.

There are only a few contraindications, and fortunately these are rather rare.

Caution is also advised if you are allergic to any of the additives in capsules. Saccharomyces boulardii should also not be taken if you have a yeast allergy.

Seriously ill or immunosuppressed persons and patients with a central venous catheter should also refrain from taking it. Not only direct ingestion can be dangerous here, but also indirect contact with the yeast fungus (e.g. through contact with a person who still has Saccharomyces boulardii traces on their hands).

Additional ingredients

Capsules containing Saccharomyces boulardii in particular usually contain various additives. This is usually not a problem, as these are also well tolerated by healthy people.

saccharomyces-boulardii-test

Gelatine is not only found in sweets. It is also sometimes found in the capsules of supplements. When buying gelatine, you should therefore pay close attention to the ingredients. (Pixabay)

If you have allergies or a special diet, you should take a closer look at the ingredients. The following substances are found in different products in different compositions.

  • Gelatine: Classically, this is obtained from bone marrow (from cattle or pigs). If you want to avoid animal products, you should pay attention to what the capsule is made of. There are also enteric-coated capsules made from vegetable substances.
  • Gluten: Gluten is sometimes used in the production of capsules. If you have coeliac disease (gluten intolerance), this can lead to unpleasant side effects, especially in severe forms. In the case of mild intolerance, one may not notice anything at all due to the very small amount.
  • Fructose: Preparations for children often contain fructose (or other sugars such as sucrose). The fructose leads to a somewhat sweet taste, but it is actually unnecessary and not really healthy in this form.
  • Other probiotics: There are also capsules that combine several probiotics. You should pay attention to what is in them and what you really need. A complex of different probiotics can also help the intestinal flora to become more stable.

The above-mentioned substances are found in many foods and preparations. If you are not aware of any particular intolerance and you are healthy, you can take Saccharomyces boulardii without hesitation.

Guide: Frequently asked questions about Saccharomyces boulardii answered in detail

In order to inform you comprehensively about the effectiveness of Saccharomyces boulardii and to give you an understanding of the current state of science, we have summarised all the important information in the following sections.

What is Saccharomyces boulardii?

Saccharomyces boulardii is a probiotic, i.e. a preparation that contains living microorganisms and is intended to support the body in its processes. Particularly common probiotics are, for example, lactic acid bacteria, which are found in sauerkraut, among other things.

Saccharomyces boulardii is an officially approved medicinal yeast. It is also called Saccharomyces Cerevisiae Hansen CBS 5926. (1)

saccharomyces-boulardii-test

Even though the yeast fungus is very closely related to brewer's yeast, Saccharomyces boulardii is not to be confused with yeast for baking or brewing beer. (Meritt Thomas / Unsplash)

A high-quality preparation contains a certain number of viable microorganisms, which become active in the gut after ingestion. Nowadays, the yeast fungi are freeze-dried during production and processed into a powder. In the past, the pills or powder had to be stored in the refrigerator.

Saccharomyces boulardii is an approved medicine and is not normally harmful.

How does Saccharomyces boulardii work?

These yeast fungi only work in the intestines; they have no effect or are unable to survive in other parts of the body. Since the yeast fungus itself is not a bacterium and also only attacks bacteria, it can be used well during or after taking antibiotics. (2)

As soon as the fungus arrives in the intestine, it colonises the intestinal wall. There it has a positive effect in various ways.

  • Bacteria: It attracts harmful bacteria and binds them, they are then excreted together with the yeast fungi.
  • Surface: It removes any damage to the surface and can bind harmful fluids.
  • Lower layers: The fungus makes the cells in the intestine move closer together again. This can mean that harmful bacteria can no longer penetrate so easily.

These different modes of action of Saccharomyces boulardii can help to stop existing diarrhoea earlier. But also prophylactically, they can ensure a better intestinal flora.

When and for whom is it useful to take Saccharomyces boulardii?

In principle, Saccharomyces boulardii is approved for children from the age of two. For the exact dosage, see the description and package insert of the respective product.

Intended use intake
Acute diarrhoea of any origin taking Saccharomyces boulardii can stabilise the intestine and inhibit diarrhoea until the symptoms have passed. Medication should only be used here in a very targeted and short-term manner. Diarrhoea can also be a cleansing mechanism. (3)
Prevention of travellers' diarrhoea You can take Saccharomyces boulardii not only for acute diarrhoea, but also as a preventive measure 5 days before your trip until you return.
Antibiotics patients A very common side effect of antibiotics is diarrhoea. This can be treated very well with Saccharomyces boulardii. (2)
Acne / skin diseases There have been cases where taking Saccharomyces boulardii alone has cured acne. But even if you are already taking medication, the yeast fungus can help the body in addition. More research is currently being done on the connection between the gut and the skin. In the case of severe skin diseases, discuss the intake with your doctor.
General improvement of the intestinal flora It has been known for a long time that a healthy intestinal flora can have many positive effects on humans. That is why Saccharomyces boulardii can also be taken to improve general well-being.

You see, Saccharomyces boulardii can help in really many situations. (4) And research is still being done with this yeast fungus. It was also discovered that it is not suitable for use in severe immune disorders.

What types of Saccharomyces boulardii are there and which one is right for you?

Saccharomyces boulardii is a clearly defined medicinal yeast. It is usually taken as a capsule or powder. Less frequently, it is also taken as a premixed solution. We will take a closer look at these options here.

Type Description
Capsule form Capsules are usually used. These are uncomplicated and easy to handle. The enteric-coated capsule also helps the active ingredient to reach the intestine as directly as possible.
Powder If you have difficulty swallowing, taking capsules is often unpleasant. A powder is just the right thing. It can simply be stirred into water and taken as a solution. Saccharomyces boulardii taken in this way are usually dosed somewhat higher, as they first have to pass through the gastrointestinal tract. (5)
Pre-mixed preparations are rather rare. The advantage of these is that they are already pre-dosed and the manufacturer can also add a flavour to the solution.

With these forms, there is something suitable for everyone. Of course, there are also different manufacturers of each type. You should pay special attention to the exact ingredients and buy high-quality products.

What are the side effects of Saccharomyces boulardii?

Saccharomyces boulardii is well tolerated by most people. Side effects are very rare because the active ingredient only works in the intestines and does not pass into the blood. Even if you take a little too much. (6)

In rare cases, the yeast fungus can cause flatulence, hypersensitivity reactions or fever. The likelihood of flatulence is much higher than for the other side effects.

If you experience side effects after taking Saccharomyces boulardii, stop taking it and check whether this was really the cause. If so, you can also discuss this with your doctor or pharmacist.

If a venous catheter is in place, the fungi can enter the bloodstream. It can also be dangerous if you have a severe immune disorder. (9)

What alternatives are there to Saccharomyces boulardii?

There are various products and home remedies for diarrhoea. The great advantage of Saccharomyces boulardii is that it is a yeast fungus and is therefore not attacked by antibiotics. As a rule, however, there is nothing to be said against foods that contain probiotic substances.

In the case of severe or chronic illnesses, you should discuss taking medicines or drugs with your doctor. In the worst case, you may harm your body more than you help it. You can get anti-diarrhoea medicines from your doctor (over-the-counter medicines are also available in pharmacies).

saccharosaccharomyces-boulardii-testmycsaccharomyces-boulardii-testes-boulardii-test

Fermented foods, such as sauerkraut or Korean kimchi, can also help the intestinal flora to become more stable due to the probiotics they contain. (Micah Tindell / Unsplash)

Acute diarrhoea in particular is usually a cleansing function of the intestines. In this case, it is important to replenish the body with the lost electrolytes and salts. This can be done with a simple solution of water, salt, sugar and some orange juice or bananas (the WHO recommendation for quantities can be found, for example, at www.sos.de/who-trinkloesung-bei-durchfall).

Probiotics are available in many forms, as food supplements or naturally occurring in food. There have also been some scientific studies on this topic. In principle, the intake of probiotics can positively influence and stabilise the intestinal flora. (7)

Where does Saccharomyces boulardii occur?

Saccharomyces boulardii were first researched by the French discoverer Henri Boulard. He found out that during the cholera pandemic in the 1920s, the locals chewed on the peels of lychees and mangosteen to treat the symptoms (diarrhoea).

He then isolated the yeast strand from these peels and thus began the medicinal development of Saccharomyces boulardii. (8) Saccharomyces boulardii is not to be confused with brewer's yeast or yeast for baking.

How much do Saccharomyces boulardii products cost?

Compared to the benefits Saccharomyces boulardii products can bring, the prices are relatively low. When buying Saccharomyces boulardii products you should pay attention to the ingredients they contain and that they are high-quality products in the right dosage. Many of the products on offer are highly dosed. It also requires a certain minimum amount of microorganisms for the preparation to work. (10)

Prices vary widely, ranging from 10 to 80 cents per capsule. Low prices per capsule are not necessarily a sign of poor quality; the larger the quantity, the cheaper the capsules will be in relation. When buying, it is therefore also important to pay attention to reviews and experience reports.

Image: 123rf.com/ 117562735

References (10)

1. Stier H, Bischoff SC. Influence of Saccharomyces boulardii CNCM I-745on the gut-associated immune system. Clin Exp Gastroenterol. 2016 Sep 13;9:269-279. doi: 10.2147/CEG.S111003. PMID: 27695355; PMCID: PMC5027949.
Source

2. Zhang DM, Xu BB, Yu L, Zheng LF, Chen LP, Wang W. [A prospective control study of Saccharomyces boulardii in prevention of antibiotic-associated diarrhea in the older inpatients]. Zhonghua Nei Ke Za Zhi. 2017 Jun 1;56(6):398-401. Chinese. doi: 10.3760/cma.j.issn.0578-1426.2017.06.003. PMID: 28592037.
Source

3. Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014 Jul;134(1):e176-91. doi: 10.1542/peds.2013-3950. PMID: 24958586.
Source

4. Billoo AG, Memon MA, Khaskheli SA, Murtaza G, Iqbal K, Saeed Shekhani M, Siddiqi AQ. Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea. World J Gastroenterol. 2006 Jul 28;12(28):4557-60. doi: 10.3748/wjg.v12.i28.4557. PMID: 16874872; PMCID: PMC4125647.
Source

5. Chen QF, Zhang YW. [Clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia]. Zhongguo Dang Dai Er Ke Za Zhi. 2018 Feb;20(2):116-120. Chinese. doi: 10.7499/j.issn.1008-8830.2018.02.007. PMID: 29429459; PMCID: PMC7389243.
Source

6. Kollaritsch H, Holst H, Grobara P, Wiedermann G. Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Ergebnisse einer plazebokontrollierten Doppelblindstudie [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr Med. 1993 Mar 30;111(9):152-6. German. PMID: 8486328.
Source

7. Ali R. The Use of Probiotic with ORS and ORS Only in Children with Acute Diarrhea. J Coll Physicians Surg Pak. 2019 Dec;29(12):1179-1182. doi: 10.29271/jcpsp.2019.12.1179. PMID: 31839091.
Source

8. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010 May 14;16(18):2202-22. doi: 10.3748/wjg.v16.i18.2202. PMID: 20458757; PMCID: PMC2868213.
Source

9. Rote Hand Brief: "Neue Kontraindikation von Saccharomyces boulardii (Saccharomyces cerevisiae HANSEN CBS 5926) bei schwerkranken oder immunsupprimierten Patienten"
Source

10. Williams NT. Probiotics. Am J Health Syst Pharm. 2010 Mar 15;67(6):449-58. doi: 10.2146/ajhp090168. PMID: 20208051.
Source

Why you can trust me?

Wissenschaftlicher Review
Stier H, Bischoff SC. Influence of Saccharomyces boulardii CNCM I-745on the gut-associated immune system. Clin Exp Gastroenterol. 2016 Sep 13;9:269-279. doi: 10.2147/CEG.S111003. PMID: 27695355; PMCID: PMC5027949.
Go to source
Klinische Studie
Zhang DM, Xu BB, Yu L, Zheng LF, Chen LP, Wang W. [A prospective control study of Saccharomyces boulardii in prevention of antibiotic-associated diarrhea in the older inpatients]. Zhonghua Nei Ke Za Zhi. 2017 Jun 1;56(6):398-401. Chinese. doi: 10.3760/cma.j.issn.0578-1426.2017.06.003. PMID: 28592037.
Go to source
Wissenschaftlicher Review
Feizizadeh S, Salehi-Abargouei A, Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014 Jul;134(1):e176-91. doi: 10.1542/peds.2013-3950. PMID: 24958586.
Go to source
Klinische Studie
Billoo AG, Memon MA, Khaskheli SA, Murtaza G, Iqbal K, Saeed Shekhani M, Siddiqi AQ. Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea. World J Gastroenterol. 2006 Jul 28;12(28):4557-60. doi: 10.3748/wjg.v12.i28.4557. PMID: 16874872; PMCID: PMC4125647.
Go to source
Wissenschaftliche Studie
Chen QF, Zhang YW. [Clinical effect of Saccharomyces boulardii powder combined with azithromycin sequential therapy in treatment of children with diarrhea secondary to Mycoplasma pneumoniae pneumonia]. Zhongguo Dang Dai Er Ke Za Zhi. 2018 Feb;20(2):116-120. Chinese. doi: 10.7499/j.issn.1008-8830.2018.02.007. PMID: 29429459; PMCID: PMC7389243.
Go to source
Klinische Studie
Kollaritsch H, Holst H, Grobara P, Wiedermann G. Prophylaxe der Reisediarrhöe mit Saccharomyces boulardii. Ergebnisse einer plazebokontrollierten Doppelblindstudie [Prevention of traveler's diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study]. Fortschr Med. 1993 Mar 30;111(9):152-6. German. PMID: 8486328.
Go to source
Klinische Studie
Ali R. The Use of Probiotic with ORS and ORS Only in Children with Acute Diarrhea. J Coll Physicians Surg Pak. 2019 Dec;29(12):1179-1182. doi: 10.29271/jcpsp.2019.12.1179. PMID: 31839091.
Go to source
Wissenschaftlicher Review
McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010 May 14;16(18):2202-22. doi: 10.3748/wjg.v16.i18.2202. PMID: 20458757; PMCID: PMC2868213.
Go to source
Wissenschaftlicher Review
Rote Hand Brief: "Neue Kontraindikation von Saccharomyces boulardii (Saccharomyces cerevisiae HANSEN CBS 5926) bei schwerkranken oder immunsupprimierten Patienten"
Go to source
Wissenschaftlicher Review
Williams NT. Probiotics. Am J Health Syst Pharm. 2010 Mar 15;67(6):449-58. doi: 10.2146/ajhp090168. PMID: 20208051.
Go to source
Reviews